Flavones and flavonols are molecules present in most plants that are an important component of some human diets. Epidemiological evidence shows the beneficial effects of these molecules in cardiovascular and neuropathological diseases. Experimental evidence in vitro and in vivo has confirmed the neuroprotective effects in neurons in culture against oxidative insults and in models of focal ischemia and experimental parkinsonism. Nevertheless, the active concentration range in vitro is very narrow, and effects on brain pathology have been shown mostly after chronic administration. Although the preventive effects of flavones and flavonols in brain pathology could be considered mostly substantiated, the positive neuroprotective activity after acute administration still deserves more research.

​

​

​

The natural plant flavonoid apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes

​

Abstract

Oxidative stress contributes to the progression of neurodegenerative diseases of the central and peripheral nervous systems, including Alzheimer's disease, Parkinson's disease, stroke, and diabetic neuropathy. Despite the greater capability of peripheral nerves to regenerate compared with those in the brain or spinal cord, chronic oxidative stress leads to irreversible neurodegeneration in peripheral nerves. Thus, many efforts have been made to defend against irreversible peripheral nerve degeneration and oxidative stress. Numerous phytochemicals have been revealed as antioxidants which neutralize free radicals and reduce peripheral neurocellular damage. Among them, polyphenols alleviate neurodegeneration by interacting with reactive oxygen species. Apigenin is a polyphenol found in plant-derived foods, including parsley, thyme, celery, and chamomile tea. Apigenin has been reported to exert antioxidative effects by scavenging free radicals. In particular, apigenin has a neuroprotective effect against oxidative stress in neurological disorders, such as cerebral ischemia. However, to date, no studies have shown an association of the inhibitory effect of apigenin with peripheral nerve degeneration. In this work, we showed that apigenin has a neuroprotective effect against peripheral nerve degeneration according to four key phenotypes: axonal degradation, myelin fragmentation, trans-dedifferentiation, and proliferation of Schwann cells via Krox20- and extracellular signal-regulated kinase-independent processes. Thus, apigenin could be a good candidate to treat peripheral neurodegenerative diseases.

​

Kim M, Jung J, Jeong NY, Chung HJ. The natural plant flavonoid apigenin is a strong antioxidant that effectively delays peripheral neurodegenerative processes. Anat Sci Int. 2019 Sep;94(4):285-294. doi: 10.1007/s12565-019-00486-2. Epub 2019 Apr 4. PMID: 30949912.